Status:
COMPLETED
Immunogenicity of High-dose Inactivated, Split-virion Influenza Vaccine Versus Standard Fluzone Vaccine in the Elderly
Lead Sponsor:
Sanofi Pasteur, a Sanofi Company
Conditions:
Orthomyxoviridae Infection
Influenza
Eligibility:
All Genders
65+ years
Phase:
PHASE3
Brief Summary
Compared to young adults, the elderly mount a lower antibody response to vaccination. Thus, improvement of the immune response to influenza vaccination in this age group, which is at higher risk for i...
Eligibility Criteria
Inclusion
- Aged ≥ 65 years on the day of vaccination.
- Informed consent form signed.
- Medically stable. (Subjects may have underlying chronic conditions such as hypertension, diabetes, ischemic heart disease, or hypothyroidism, as long as their symptoms/signs are controlled. If they are on medication for a condition, the medication dose must have been stable for at least 3 weeks preceding vaccination.)
- Able to attend all scheduled visits and to comply with all trial procedures.
Exclusion
- Systemic hypersensitivity to eggs, chicken proteins, or any of the vaccine components, or a history of a life-threatening reaction to the standard-dose Fluzone® vaccine or a vaccine containing any of the same substances.
- Congenital or history of acquired immunodeficiency, or immunosuppressive therapy such as anti-cancer chemotherapy or radiation therapy within the preceding six months.
- Systemic corticosteroid therapy, as follows:
- Continuous use with a dosage equivalent to \> 15 mg/day of oral prednisone for 90 days preceding vaccination.
- Sporadic use with a dosage equivalent to \> 40 mg/day of oral prednisone for \> 14 consecutive days in the 90 days preceding vaccination.
- Note:Use of topical or inhalant corticosteroids is acceptable.
- Neoplastic disease or any hematologic malignancy (except localized skin or prostate cancer that is stable at the time of vaccination in the absence of therapy, as well as subjects who have a history of neoplastic disease and who have been disease-free for ≥ 5 years).
- Current alcohol abuse or drug addiction that in the opinion of the investigator may interfere with the subject's ability to comply with trial procedures.
- Receipt of blood or blood-derived products in the past three months.
- Participation in a trial of a high-dose influenza vaccine in the past 12 months.
- Receipt of influenza vaccine in the past six months.
- Receipt of any other vaccine in the past four weeks.
- Planned receipt of any other vaccine in the four weeks following the trial vaccination.
- Participation in another clinical trial in the past four weeks.
- Planned participation in another clinical trial during the present trial period.
- Note:Concomitant participation in an observational trial (not involving drugs, vaccines, or medical devices) is acceptable.
- Thrombocytopenia or bleeding disorder contraindicating intramuscular (IM) vaccination.
- History of Guillain-Barré syndrome.
- Subject deprived of freedom by an administrative or court order, or in an emergency setting, or hospitalized without his/her consent.
- An acute febrile illness (oral temperature ≥ 99.5ºF \[≥ 37.5ºC\]) within 24 hours prior to vaccination. If this contraindication exists, vaccination will be deferred until the participant has been afebrile for at least 24 hours.
- Signs and symptoms of an acute infectious respiratory illness. If this exists, vaccination will be deferred until the symptoms resolve.
Key Trial Info
Start Date :
October 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2008
Estimated Enrollment :
3851 Patients enrolled
Trial Details
Trial ID
NCT00391053
Start Date
October 1 2006
End Date
February 1 2008
Last Update
April 14 2016
Active Locations (28)
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1
Mesa, Arizona, United States
2
Phoenix, Arizona, United States
3
Tempe, Arizona, United States
4
Tucson, Arizona, United States