Status:
COMPLETED
Examination of Idiopathic Hypogonadotropic Hypogonadism (IHH)and Kallmann Syndrome (KS)
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Kallmann Syndrome
Hypogonadotropic Hypogonadism
Eligibility:
All Genders
16+ years
Phase:
PHASE1
Brief Summary
The purpose of the study is to examine how Kallmann syndrome (KS) and idiopathic hypogonadotropic hypogonadism (IHH) affect reproductive hormones. These disorders are caused by a defect in Gonadotropi...
Detailed Description
The specific aims of this study are: * To identify men and women with hypogonadotropic hypogonadism and to define the spectrum of abnormalities in GnRH secretion in these patients. * To study the phy...
Eligibility Criteria
Inclusion
- Eligibility
- Ages Eligible for Study:
- Adolescents (16-17yrs)
- Adults (18 years and older)
- Genders Eligible for Study:
- Male and Female
- Accepts Healthy Volunteers:
- No
- Criteria
- adolescent boys (age 16-17 years) and adult male individuals (age 18 years and older) with a single serum sample demonstrating low testosterone in association with low or inappropriately normal gonadotropin levels
- adolescent girls (age 16-17 years) and adult female individuals (age 18 years and older) with a single serum sample demonstrating low estradiol (estrogen) in association with low or inappropriately normal gonadotropin levels
- suitable male and female hypogonadotropic hypogonadal subjects
Exclusion
- no specific exclusion criteria
Key Trial Info
Start Date :
April 1 1989
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 16 2019
Estimated Enrollment :
624 Patients enrolled
Trial Details
Trial ID
NCT00392756
Start Date
April 1 1989
End Date
May 16 2019
Last Update
July 11 2022
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114-2696