Status:
COMPLETED
Correlation of Urinary Kallikrein With Cytokines, Proteinuria and Renal Function in Chronic Renal Disease Patients
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Chronic Kidney Disease
Eligibility:
All Genders
20-70 years
Brief Summary
Urinary kallikrein excretion is known to increase in patients with nephrotic syndrome and sick cell disease, but decrease in patients with chronic kidney disease or uremia. Some of authors consider ur...
Eligibility Criteria
Inclusion
- During June 2004 and June 2005 who participate the clinical study "Efficacy of Pentoxifylline on Chronic Kidney Disease" (ClinicalTrials.gov Identifier: NCT00155246)and sign the informed consent.
- Chronic kidney disease history \> 3 months, Serum creatinine: 1.1\~6.0 mg/dl in female. 1.3\~6.2 mg/dl in male.
- Initial Random urine protein (mg/dl) /creatinine (mg/dl) ratio \> 0.5
Exclusion
- History of allergy to pentoxifylline;
- females are nursing or pregnant;
- Obstructive uropathy;
- Unable to stop chronic immunosuppressive therapy, NSAID;
- Congestive heart failure (New York Heart Association functional class III or IV);
- Unstable angina, myocardial infarction, coronary artery bypass graft surgery, percutaneous coronary intervention, within the past 6 months prior to signing the informed consent form;
- Cerebral hemorrhage within the past 6 months prior to signing the informed consent form;
- Retinal hemorrhage within the past 6 months prior to signing the informed consent form;
- Known or suspected secondary hypertension (e.g., primary aldosteronism, renovascular hypertension, pheochromocytoma);
- Severe uncontrolled hypertension with SBP \> 220 mmHg and/or DBP \> 115 mmHg;
- Hepatic dysfunction as defined by the following laboratory parameters: ALT or AST \> 2 times the upper limit of the normal range;
- Biliary obstructive disorders (e.g. cholestasis);
- Active malignancy
Key Trial Info
Start Date :
October 1 2006
Trial Type :
OBSERVATIONAL
End Date :
October 1 2006
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00395005
Start Date
October 1 2006
End Date
October 1 2006
Last Update
March 23 2007
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.