Status:
COMPLETED
Treating Refractory Obsessive Compulsive Disorder With rTMS
Lead Sponsor:
Centre for Addiction and Mental Health
Conditions:
Obsessive Compulsive Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Obsessive-compulsive disorder (OCD) is a severe psychiatric condition with only limited response to current first-line treatments, comprising pharmacotherapy and cognitive-behavioural therapy. Repetit...
Detailed Description
Obsessive-compulsive disorder (OCD) is a severe and debilitating psychiatric illness characterized by intrusive unwanted thoughts (obsessions) and repetitive or ritualistic actions intended to reduce ...
Eligibility Criteria
Inclusion
- voluntary and competent to consent based on their ability to provide a spontaneous narrative description of the key elements of the study
- have a Structured Clinical Interview for DSM-IV (SCID) confirmed diagnosis of OCD
- are between the ages of 18 and 65
- have failed to achieve a clinical response, or did not tolerate, at least 3 separate antidepressant trials of sufficient dose for at least 10 weeks
- have a score of greater than or equal to 17 on the Y-BOCS. A careful medical and neurological history will be taken to ensure that subjects have no unstable conditions that would preclude them from entering into the study. This history will focus on conditions such as seizures, stroke, hypertension, diabetes, coronary artery disease, thyroid problems, respiratory illness, allergies and presence of metal implants
Exclusion
- have a history of DSM-IV substance dependence in the last 6 months, and have DSM-IV substance abuse in the last month
- have a concomitant major unstable medical or neurologic illness or have had a history of seizures
- acutely suicidal
- are pregnant
- have metal implants. With respect to concomitant medications, patients will be excluded if they are currently (or in the last 4 weeks) taking: (a) more than lorazepam 2 mg daily (or equivalent), (b) monoamine oxidase inhibitors, (c) and/or bupropion due to its associated increased risk for seizures.
Key Trial Info
Start Date :
June 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT00396552
Start Date
June 1 2006
End Date
December 1 2011
Last Update
February 15 2013
Active Locations (2)
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1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
2
Centre for Addiction and Mental Health
Toronto, Ontario, Canada, M5T 1R8