Status:
COMPLETED
Evaluation of the Antihypertensive Effect of Hyzaar(R) and Cognitive Function of Hypertensive Patients (0954A-322)
Lead Sponsor:
Organon and Co
Conditions:
Hypertension
Eligibility:
All Genders
50+ years
Phase:
PHASE3
Brief Summary
Evaluate the antihypertensive and neuroprotective effects of Hyzaar(R) in elderly subjects in comparison with Natrilix(TM).
Eligibility Criteria
Inclusion
- ACEi or ARB naive or not taking ACEi or ARB concurrently for at least one month before the run-in period
- Be able to carry out his or her own daily activity
- \- Be at least 50 years old at inclusion in the study Be diagnosed with mild to moderate hypertension, treated or untreated
- Literate
- Not taking any cognitive-enhanced agent at baseline
- Present with a memory complain ( spontaneous or informed by caregiver)
Exclusion
- Congestive heart failure with NYHA class \>2
- Renal failure or renal insufficiency with serum creatinine \>1.4mg/dl
- chronic severe liver disease with abnormal GPT and GOT \>2 times of upper normal limits
- Diagnosed with major depression when entering the study
- Foreign language as his or her mother tongue so that the test results will not be reliable
- History of stroke or transient ischemic attack (stroke is defined as focal neurological sign progressing stepwise)
- Hypersensitive to the active ingredient and any other component of losartan potassium and indapamide tablets
- Major hearing loss/deafness and/or major visual impairment/blindness preventing from performing the tests
- Myocardial infarction within the past 6 months
- Single functioning kidney
- Anuria
Key Trial Info
Start Date :
March 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2007
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT00398541
Start Date
March 1 2005
End Date
June 1 2007
Last Update
August 15 2024
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