Status:
COMPLETED
Assessment of Noninvasive Methods to Identify Patients at Risk of Serious Arrhythmias After a Heart Attack
Lead Sponsor:
University of Calgary
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Heart and Stroke Foundation of Canada
Conditions:
Myocardial Infarction
Death, Sudden, Cardiac
Eligibility:
All Genders
18+ years
Brief Summary
This study evaluates the usefulness of noninvasive tests of the structure of the heart and the nervous system controlling the heart. It will assess whether combining tests that evaluate heart structur...
Detailed Description
Background. Sudden cardiac death (SCD) kills \>450,000 North Americans each year. Patients with a history of myocardial infarction (MI) are at particular risk. Concurrent alterations in myocardial str...
Eligibility Criteria
Inclusion
- Confirmed MI \<31 days, based upon elevated cardiac-specific CK (total CK-MB mass \>7ng/mL or CK-MB/total CK ≥ 2.5%) or troponin-T (\> 0.1 ng/ml)144) plus
- clinical symptoms or ECG evidence of myocardial injury (ST deviation ≥ 1 mm in 2, contiguous leads or new/previously undocumented Q waves)144, \&
- left ventricular ejection fraction ≤ 0.40 within 48 hrs or ≤ 0.50 beyond 48 hrs of MI using (echocardiography, radionuclide or contrast angiography) \&
- Sinus rhythm at the time of enrollment.
Exclusion
- Geographic isolation or inability to return for follow-up,
- Comorbid illness likely to cause death within 24 months,
- Inability to complete a submaximal exercise test (e.g., urgent CABG),
- Class I indication for a defibrillator (e.g., VF or sustained VT \> 48 hours of index MI), or
- Lack of written informed consent
Key Trial Info
Start Date :
September 1 2001
Trial Type :
OBSERVATIONAL
End Date :
December 1 2007
Estimated Enrollment :
350 Patients enrolled
Trial Details
Trial ID
NCT00399503
Start Date
September 1 2001
End Date
December 1 2007
Last Update
June 14 2016
Active Locations (1)
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1
Foothills Hospital
Calgary, Alberta, Canada, T2N4N1