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Status:

COMPLETED

A First Time In Human Study To Assess The Compound GSK615915

Lead Sponsor:

GlaxoSmithKline

Conditions:

Bronchospasm

Eligibility:

All Genders

18-60 years

Phase:

PHASE1

Brief Summary

GSK615915A is being developed as a novel surfactant for use in the formulation of GSK's future generation of Metered Dose Inhalers (MDIs). A surfactant in a MDI would provide a more stable drug suspen...

Eligibility Criteria

Inclusion

  • Women of non-child bearing potential.
  • Body weight = 50 kg (110 lbs) for men and = 45 kg for women and Body Mass Index (BMI) within the range 19.0-30.0 kg/m²
  • The subject is a current non-smoker who has not used any tobacco products in the last 12 months with a pack history of = 10 pack years.
  • The subject has demonstrated the ability to correctly use a metered dose inhaler device.
  • If asthmatic:
  • The subject must be clinically stable The subject has a baseline FEV1 = 80% of predicted.

Exclusion

  • As a result of the medical interview, physical examination or screening investigations, the Physician Responsible considers the volunteer unfit for the study.
  • The subject has a history of allergy to excipients, MDI propellants, or a history of drug or other allergy that, in the opinion of the physician responsible makes the volunteer unfit to participate.
  • The subject has recently participated in another clinical trial.
  • The subject has used prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John’s Wort) within 7 or 14 days.
  • The subject has an average weekly alcohol intake of greater than 21 units if male or 14 units if female, or an average daily intake of greater than 3 units regularly, where 1 unit is equivalent to a half-pint (220mL) of beer or 1 (25ml) measure of spirits or 1 glass (125ml) of wine.
  • Any history of breathing problems (e.g. history of asthmatic symptoms).
  • The subject is infected with the hepatitis B, hepatitis C, or HIV virus.
  • The subject is has a positive drugs of abuse test.
  • The subject has had a respiratory tract infection within 4 weeks of the start of the study.
  • The subject has a past or present disease, which as judged by the Doctor, may affect the outcome of this study.
  • The subject has a history of life-threatening asthma.
  • The subject has taken inhaled, nasal or dermal steroids within 4 weeks or oral steroids within 8 weeks of the start of the study.
  • The subject has taken long acting inhaled beta 2 agonists within 96 hours before the screening visit.
  • The subject has taken short acting inhaled beta 2 agonists within 8 hours before the screening visit.
  • The subject is unable to abstain from other drugs that may interfere with the conduct of the study or its interpretation.
  • The subject has ongoing rhinitis that requires treatment.

Key Trial Info

Start Date :

November 23 2005

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

July 3 2006

Estimated Enrollment :

46 Patients enrolled

Trial Details

Trial ID

NCT00400660

Start Date

November 23 2005

End Date

July 3 2006

Last Update

September 29 2017

Active Locations (1)

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Page 1 of 1 (1 locations)

1

GSK Investigational Site

Edinburgh, West Lothian, United Kingdom, EH14 4AP