Status:
COMPLETED
Exercise Treatment of Mild-Stage Probable Alzheimer's Disease
Lead Sponsor:
Intermountain Health Care, Inc.
Collaborating Sponsors:
Deseret Foundation
Conditions:
Alzheimer Disease
Memory Disorders
Eligibility:
All Genders
65-89 years
Phase:
PHASE2
Brief Summary
The purpose of the study is to determine if participation in an exercise program helps memory loss from getting worse, and if it improves daily functioning and attitudes of those with probable Alzheim...
Detailed Description
Currently, there is no cure for the memory loss associated with Alzheimer's disease, though some medications can help it from getting worse. The research study will help to answer the question if part...
Eligibility Criteria
Inclusion
- Age is 65 through 89 years old.
- Completed more than an 8th grade education.
- Native English speaker.
- Diagnosis of probable Alzheimer's disease by a primary care physician or specialty clinic.
- Taking a cholinesterase inhibitor at a therapeutic dose for at least two weeks prior to admission to study (following minimum titration of four weeks), but no other prescribed medication for cognitive functioning (e.g., memantine/Namenda).
- May have one unstable physical illness that is being treated or a few controlled physical illnesses, is on few medications, and appears no more than mildly ill.
- Treated stable hypertension \& hyperlipidemia are permissible, but resting blood pressure must be \<170/100 mm Hg.
- Normal TSH \& Vitamin B12 levels, as confirmed by laboratory data within 3 years.
- Able to participate a three-day/week physical activity program (No orthopedic, neurologic, or behavioral limitations that may preclude exercise training) for up to 6 months.
- Patient has a knowledgeable informant who can report the day-to-day activities of participant (e.g., spouse, adult child, paid caregiver).
- Able to give assent/consent to research study.
Exclusion
- History of learning or developmental disability.
- Treatment with hormone replacement therapy during the last year.
- History of psychiatric condition (including depression).
- Evidence of serious cardiac condition or significant small vessel disease (e.g., heart bypass surgery, angina, arrhythmia, dyspnea, insulin-dependent diabetes with neuropathy, confluent white matter alterations on structural MRI or CT scan).
- History of neurologic condition (e.g., large vessel stroke, seizures, Parkinsonism).
- History of heavy metals exposure.
- History of sleep disturbance (e.g., treated apnea, insomnia).
- History of brain injury (including concussion of \>10 minutes).
- History of delirium (change in mental status due to medications) for the past year.
- No pharmaceutical treatment for mood currently, or history of longstanding depression.
Key Trial Info
Start Date :
October 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2009
Estimated Enrollment :
79 Patients enrolled
Trial Details
Trial ID
NCT00403507
Start Date
October 1 2006
End Date
October 1 2009
Last Update
May 11 2011
Active Locations (1)
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1
LDS Hospital
Salt Lake City, Utah, United States, 84143