Status:
COMPLETED
A Pilot Study of Effect of Dexmedetomidine on Sleep and Inflammation in Critically Ill Patients
Lead Sponsor:
University of Arizona
Conditions:
Sleep
Critical Illness
Eligibility:
All Genders
21-85 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to assess the short-term effect of sympatholysis on sleep quality and inflammation in critically ill patients.
Detailed Description
Over 1 million patients receive mechanical ventilation every year in the United States. In mechanically ventilated patients, despite sedative infusions, sleep is severely disrupted. Sleep disruption, ...
Eligibility Criteria
Inclusion
- Patients requiring mechanical ventilation with a diagnosis of
- Acute Respiratory Distress Syndrome
- Cardiogenic Pulmonary Edema
- Pneumonia
- Chronic obstructive pulmonary disease
Exclusion
- Patients who are considered too unstable to undergo this investigation by their primary physician
- Comatose patients, or patients with severe debilitating neurological disease
- Renal insufficiency (Sr. Creatinine \> 2 mg/dL)
- Heart block (second or third degree heart block) or sinus bradycardia (heart rate \< 60 beats per minute)
- Pregnancy
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2007
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT00405847
Start Date
July 1 2006
End Date
May 1 2007
Last Update
October 27 2016
Active Locations (1)
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1
Southern Arizona VA Healthcare System
Tucson, Arizona, United States, 85723