Status:
COMPLETED
Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis
Lead Sponsor:
Hopital Lariboisière
Collaborating Sponsors:
Ministry of Health, France
Conditions:
Bacteremia
Gram-Negative Bacterial Infections
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The impact of continuous veno-venous haemofiltration (CVVH) on sepsis-induced multiple organ failure severity is controversial. We thus sought to assess the effect of early application of haemofiltrat...
Detailed Description
prospective, randomized, open, multicentre study was performed between 1997 and 1999 in 16 French intensive care units. Patients were enrolled within 24 hours of development of the first organ failure...
Eligibility Criteria
Inclusion
- clinically identified focus of infection associated with at least 2 SIRS criteria and one or more sepsis-induced organ failures within the 24 hours prior to inclusion, plus a SAPS II score between 35-63
Exclusion
- Patients were excluded if pregnant, younger than 18 years, in a moribund state, in chronic renal failure, or receiving immunosuppressive therapy.
Key Trial Info
Start Date :
March 1 1997
Trial Type :
INTERVENTIONAL
End Date :
December 1 1999
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT00406198
Start Date
March 1 1997
End Date
December 1 1999
Last Update
December 4 2006
Active Locations (1)
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1
Lariboisiere University Hospital
Paris, France