Status:
COMPLETED
Donepezil and Brain Activity Patterns in Those at Risk For Alzheimer's Disease
Lead Sponsor:
Vanderbilt University
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
40-85 years
Phase:
PHASE1
Brief Summary
The purpose of the study is to examine patterns of brain activity in people who are at risk for memory problems (e.g., Alzheimer's disease or dementia)before and after the medication donepezil. Althou...
Detailed Description
HYPOTHESIS 1. Cognitively intact individuals with normal brain morphology at genetic risk for developing Alzheimer's' Disease (AD) show alterations in brain activation patterns during tasks that requ...
Eligibility Criteria
Inclusion
- Subjects may report experiencing subjective memory dysfunction, however they must be found by clinical evaluation to have no memory dysfunction
- Neuropsychological test battery in the normal range
- Ages 40-85
Exclusion
- Dementia (Mini-Mental State Exam less than 25/30)
- Left-handedness
- Current medication that could influence cognition
- Medical, psychiatric, and neurologic conditions, including cerebrovascular disease or uncontrolled hypertension
- Claustrophobia
- Surgical clips or implants
- Pacemakers or other implanted electronic devices
- History of sheet metal work
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 24 2012
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT00408525
Start Date
December 1 2006
End Date
August 24 2012
Last Update
February 5 2018
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212