Status:
COMPLETED
Determinants of Corticosteroid Insensitivity in Smokers With Asthma
Lead Sponsor:
University of Glasgow
Collaborating Sponsors:
Chief Scientist Office of the Scottish Government
Conditions:
Asthma
Smoking
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Smokers with asthma display a relative insensitivity to inhaled and oral corticosteroids. The causes of this phenomenon are currently unknown. The investigators will perform a number of blood \& breat...
Detailed Description
Smokers with asthma display a relative insensitivity to inhaled and oral corticosteroids. The causes of this phenomenon are currently unknown. However research into steroid resistance in severe asthma...
Eligibility Criteria
Inclusion
- Asthma (defined by either reversibility to bronchodilator or methacholine testing)
- Asthma duration of 6 months or greater
- Stable asthma
- Age 18-60
- Treatment with inhaled corticosteroids
- Smoking history consistent with group
- smokers with asthma: \> or = 5 pack years and currently smoking more than 5 cigarettes per day
- ex-smokers: smoking ceased \> or = two years prior to recruitment, minimum 5 pack year history
- non-smokers: no smoking history
Exclusion
- Presence of medical condition likely to be exacerbated by treatment with oral corticosteroids
- Treatment with \> 2000 mcg beclomethasone (or equivalent) per day
- Subject requires oral corticosteroids to maintain asthma control
- Subject requires oral theophylline to maintain asthma control
- Recent treatment with oral corticosteroids
- Pregnancy or subject planning to become pregnant
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT00411320
Start Date
January 1 2007
End Date
September 1 2010
Last Update
August 4 2011
Active Locations (1)
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1
Asthma Research Unit, Glasgow University
Glasgow, Scotland, United Kingdom, G12 0YN