Status:
COMPLETED
Vascular Remodeling and the Effects of Angiogenic Inhibition in Diabetic Retinopathy
Lead Sponsor:
National Eye Institute (NEI)
Conditions:
Diabetic Retinopathy
Eligibility:
All Genders
Phase:
EARLY_PHASE1
Brief Summary
The retinal vasculature changes dramatically in patients with diabetic retinopathy especially between non-proliferative and proliferative disease. The retinal vasculature can be imaged and quantified ...
Detailed Description
In this study, we are studying whether vascular density decreases during diabetic retinopathy prior to the pathological neovascularization seen in proliferative disease that results in blindness in mo...
Eligibility Criteria
Inclusion
- \- Presence of mild, moderate, severe, or very severe non-proliferative diabetic retinopathy (defined as ETDRS level \>10) in at least one eye (based on ETDRS criteria)
Exclusion
- Any condition that might impair the patient's ability to give informed consent
- Any condition or media opacity that might impair the patient's ability to perform vision tests, color fundus photographs or fluorescein angiography
- Severe allergy or other contraindication to sodium fluorescein dye
- Participating in any other ophthalmic clinical trial
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2009
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00411333
Start Date
July 1 2006
End Date
July 1 2009
Last Update
November 11 2010
Active Locations (1)
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1
Cole Eye Institute
Cleveland, Ohio, United States, 44195