Status:
COMPLETED
Effects of Nefopam on Hyperalgesia After Cardiac Surgery
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Hyperalgesia
Pain, Postoperative
Eligibility:
All Genders
55-75 years
Phase:
PHASE2
PHASE3
Brief Summary
Postoperative pain after major surgery is consecutive not only to the nociceptive inputs coming from the surgical lesion, but also to peripheral and central neuronal sensitization. This lead to postop...
Detailed Description
Introduction : Postoperative pain is not only a consequence of the surgical lesion, but is also related to sensitization processes that appear in peripheral and central nerves. This sensitization ind...
Eligibility Criteria
Inclusion
- 55-75 years old
- ASA score: 1-3
- Patients scheduled for Cardiac surgery with median sternotomy for : single valve replacement or Bentall or Benson or Tyron David surgery, single or multiple Cardiac Artery Bypass Grafting (CABG) , combined surgery (valve replacement + CABG) without preoperative risk of postoperative complications
- Informed consent obtained from the patient
Exclusion
- Drug or alcohol abuse history
- Analgesic or opioid consumption within the 12hs preceding the surgery
- Chronic use of analgesic drugs or history of chronic pain
- Convulsion or epilepsy history
- Glaucoma history
- Disability to understand morphine PCA use
- Allergy to nefopam
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2008
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00413257
Start Date
December 1 2006
End Date
November 1 2008
Last Update
May 28 2010
Active Locations (1)
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1
Département d'Anesthésie-Réanimation II - Hôpital cardiologique - Groupe Hospitalier Sud, CHU de Bordeaux - 4, Av de Magellan
Pessac, France, 33604