Status:
COMPLETED
Absolute Myocardial Perfusion Measurement in the Transplanted Heart
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Collaborating Sponsors:
Swiss National Science Foundation
Swiss Heart Foundation
Conditions:
Cardiac Transplantation
Eligibility:
All Genders
18-80 years
Brief Summary
The goal of this study is to detect AR and CR in the transplanted heart by quantitative assessment of myocardial blood flow and its constituents by myocardial contrast echocardiography (MCE). Further ...
Detailed Description
Heart transplantation has become an accepted therapy for end-stage heart failure. Acute allograft rejection (AR) remains a major cause of mortality in heart transplant recipients. Chronic rejection (C...
Eligibility Criteria
Inclusion
- Patients with heart transplantation, age 18-82 years
- EMB or EMB and coronary angiography
- Written informed consent to participate in the study
Exclusion
- Known adverse reaction to adenosine or echo contrast (SonoVueâ)
- Second or third degree AV block, unprotected sick sinus syndrome, atrial fibrillation with uncontrolled ventricular rate
- Asthma, severe pulmonary arterial hypertension (systolic pulmonary artery pressure \>50mmHg assessed by echocardiography)
- Severe obstructive pulmonary disease
Key Trial Info
Start Date :
December 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2009
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00414895
Start Date
December 1 2006
End Date
June 1 2009
Last Update
October 26 2010
Active Locations (1)
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1
University Hospital Inselspital
Bern, Switzerland, 3010