Status:
WITHDRAWN
Epidural Clonidine for Postoperative Hyperalgesia
Lead Sponsor:
Cambridge University Hospitals NHS Foundation Trust
Conditions:
Postoperative Hyperalgesia
Eligibility:
All Genders
18-80 years
Phase:
PHASE3
Brief Summary
We propose performing a study in which we compare the effects of bupivacaine and fentanyl with a different drug combination - bupivacaine and clonidine. The principal research questions of the study a...
Detailed Description
In addition to pain at the surgical incision site, patients undergoing major bowel operations commonly experience pain in the surrounding (uninjured)skin during the postoperative period - this phenome...
Eligibility Criteria
Inclusion
- Age 18-80 years
- Scheduled for elective major bowel surgery through a vertical midline incision
- An epidural catheter for pain relief during and after the operation is required and the patient has already consented to it.
- Good physical health or if they have any disease (e.g. heart disease, high blood pressure, asthma), it should be well controlled with medication.
Exclusion
- Previous abdominal surgery, kidney or liver disease
- Inability to understand or comply with the study protocol
- Allergy to any of the study drugs
- Failure of either placement of an epidural catheter or poor pain relief with epidural analgesia.
Key Trial Info
Start Date :
December 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00417443
Start Date
December 1 2007
End Date
December 1 2009
Last Update
January 8 2014
Active Locations (1)
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1
Addenbrooke's Hospital
Cambridge, Cambridgeshire, United Kingdom, CB1 9YJ