Status:
UNKNOWN
Manipulation of Visceral Sensitivity and Immune System in IBS
Lead Sponsor:
London North West Healthcare NHS Trust
Conditions:
Irritable Bowel Syndrome
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Irritable bowel syndrome (IBS) is a common condition. At least 20% of the population suffer from IBS. The symptoms of abdominal pain, diarrhoea, constipation, bloating and difficulty with bowel motion...
Detailed Description
This research will study 1\) probiotic-induced changes in visceral hypersensitivity and immune activity The effects of probiotic therapy will be assessed in a randomised placebo-controlled study. Sub...
Eligibility Criteria
Inclusion
- patients fulfilling the Rome II criteria for the diagnosis of IBS
- normal blood investigations
- normal colonoscopy
Exclusion
- a history of weight loss
- rectal bleeding
- fevers
- psychiatric illness (severe depression, anxiety, mania and schizophrenia)
- active infection
- recent antibiotic therapy or anti-inflammatory medication within previous 4 weeks
Key Trial Info
Start Date :
December 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00418340
Start Date
December 1 2007
Last Update
November 16 2007
Active Locations (1)
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1
North West London Hospitals NHS Trust - St Mark's
London, Middlesex, United Kingdom, HA1 3UJ