Status:
COMPLETED
Escitalopram in Depressive Patients With Acute Coronary Artery Syndrome
Lead Sponsor:
Chonnam National University Hospital
Collaborating Sponsors:
H. Lundbeck A/S
Conditions:
Depressive Disorder
Coronary Disease
Eligibility:
All Genders
18-85 years
Phase:
PHASE4
Brief Summary
This study aimed to evaluate the efficacy and safety of escitalopram in the treatment of depressive patients with acute coronary artery syndrome (CAS).
Detailed Description
Depression is common in patients with acute CAS and increases cardiac morbidity and mortality. However, there are a few limited data available regarding the effects and safety of antidepressants for t...
Eligibility Criteria
Inclusion
- Aged 18\~85
- Diagnosed as acute CAS (unstable angina or acute myocardial infarction) and being conducted coronary angiography
- Beck Depression Inventory \> 10 and major or minor depressive disorder by the DSM-IV criteria
- With ability to complete various questionnaires
- Can understand the objective of the study and sign informed consent
Exclusion
- Occurrence of acute CAS while the patient was hospitalized for another reason, except for CAS
- Current CAS developed less than 3 months after coronary artery bypass graft procedure
- Uncontrolled hypertension (systolic BP \> 180mmHg or diastolic BP \> 100mmHg)
- Resting heart rate \< 40/min
- Severe physical illnesses threatening life or interfering with the recovery from CAS
- Persistent clinically significant laboratory abnormalities
- Concomitant use of class I antiarrhythmic medications; reserpine, guanethidine, clonidine, or methyldopa; anticonvulsants or neuroleptics
- History of neuropsychiatric illnesses such as dementia, Parkinson's disease, brain tumor, psychoses, alcoholism, and other substance dependence
- Pregnancy
Key Trial Info
Start Date :
May 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2013
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00419471
Start Date
May 1 2007
End Date
March 1 2013
Last Update
June 13 2013
Active Locations (1)
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1
Chonnam National University Hospital
Gwangju, South Korea, 501-757