Status:
TERMINATED
Modulation of Regional Brain Activation in Schizophrenic Patients by Pharmacological Therapy
Lead Sponsor:
University of Jena
Collaborating Sponsors:
Sanofi
Conditions:
Schizophrenia
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
The study aims to investigate the modulation of regional brain activation in schizophrenic patients by psychopharmacological treatment with either haloperidol, amisulpride or olanzapine. The study wil...
Detailed Description
The current study aims to investigate the following issues: * Changes in cognitive activation patterns under therapy with the typical neuroleptic haloperidol as compared to the atypical antipsychotic...
Eligibility Criteria
Inclusion
- In- and outpatients of either sex
- Able to comply with the protocol
- Having given their written informed consent of their own free will
- Total BPRS (PANSS-derived, 1-7 points) minimum 36 points at baseline
- Schizophrenic or schizophreniform disorder according to DSM-IV criteria (295.10, .30, .40, .90)
- Definite right-handedness (according to the modified Edinburgh Handedness Inventory)
- Age 18 - 50 years
Exclusion
- Co-morbid psychiatric axis I disorder (DSM-IV) other than schizophrenia
- Axis II disorder according to DSM-IV
- Present or past history of substance and drug dependence (including alcohol dependence)
- Participation in a clinical trial within the previous three months
- Lack of insight
- Suicidal ideations or aggression against others
- Consumption of caffeine-containing beverages within 6 hours before assessments
- Clinically significant findings in ECG or EEG
- Known intolerance against neuroleptics
Key Trial Info
Start Date :
January 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2007
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT00419653
Start Date
January 1 2003
End Date
September 1 2007
Last Update
September 16 2008
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