Status:
COMPLETED
Effect of Enalapril and Losartan Association Therapy on Proteinuria and Inflammatory Biomarkers in Diabetic Nephropathy: a Clinical Trial on Type 2 Diabetes Mellitus
Lead Sponsor:
University of Sao Paulo
Collaborating Sponsors:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conditions:
Macroalbuminuric Diabetic Nephropathy
Eligibility:
All Genders
30+ years
Phase:
PHASE4
Brief Summary
Chronic kidney disease (CKD)has become a significant health problem worldwide. Strategies to decrease the rate of progression of this disease and reduce the number of patients needing dialysis or rena...
Detailed Description
Diabetic kidney disease is the current leading cause of chronic kidney disease (CKD) in the world. Despite all efforts to control this disease, rates of CKD progression are still high and a significan...
Eligibility Criteria
Inclusion
- diabetic nephropathy characterised by a daily proteinuria superior to 500 mg
- type II diabetes
Exclusion
- type 1 diabetes
- serum creatinine \> 2.5 mg/dL or creatinine clearance lower than 30 ml/min
- serum potassium \> 5.5 mEq/L
- intolerance or allergy to ACE inhibitors or BRA
- pregnancy
- hepatitis C or B
- HIV
- current chemotherapy treatment
Key Trial Info
Start Date :
May 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2007
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00419835
Start Date
May 1 2005
End Date
September 1 2007
Last Update
August 4 2011
Active Locations (1)
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1
Nephrology Department, Sao Paulo University Medical School
São Paulo, São Paulo, Brazil, 05403-010