Status:
COMPLETED
Dietary Advanced Glycation End-products and Insulin Resistance in Overweight and Obese Humans
Lead Sponsor:
Bayside Health
Conditions:
Type 2 Diabetes
Insulin Resistance
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
We hypothesize that reduction in dietary advance glycation endproducts (AGE) intake will increase insulin sensitivity and normalise insulin secretion in overweight and obese individuals through reduct...
Eligibility Criteria
Inclusion
- weight stable overweight and obese (BMI ≥ 25kg/m2) non-diabetic individuals, aged 18-50 years and healthy according to medical history, blood biochemistry and physical examination.
Exclusion
- Participants will be excluded if they:
- are aged \<18 years or \> 50 years;
- currently smoke, have high alcohol use; or a positive urine drug screening test;
- have a history of: diabetes, cardiovascular and hematological disease, respiratory, gastrointestinal, endocrine, renal or central nervous system disease, psychosis or psychiatric disorder, active cancer within last 5 years.
- are actively seeking to lose weight, or if their weight has changed by more than 10 kilograms in the previous 12 months.
- have been taking medication within one month prior to commencing the study;
- have acute inflammation (by history, physical or laboratory examination)
- are on hormonal contraceptives, or pregnant (by HCG urine pregnancy screening test) or lactating
- have highly unusual dietary habits or follow vegan diets (because of the difficulty in complying with the assigned diet).
- have current diabetes (determined by history and/or 75g glucose OGTT)
- are unable to provide informed consent
Key Trial Info
Start Date :
November 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT00422253
Start Date
November 1 2006
End Date
December 1 2012
Last Update
December 16 2013
Active Locations (1)
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1
Baker Heart Research Insitute
Melbourne, Victoria, Australia, 3186