Status:
UNKNOWN
Rifampin Combination Therapy Versus Monotherapy in Early Staphylococcal Infections After Total Hip and Knee Arthroplasty
Lead Sponsor:
Oslo University Hospital
Conditions:
Prosthesis-related Infections
Staphylococcal Infections
Eligibility:
All Genders
Phase:
PHASE4
Brief Summary
The number of patients requiring joint replacement is increasing due to its success in restoring function and pain relief, and the growing population of the elderly. One of the most serious complicati...
Detailed Description
The study is a controlled randomized multicentre trial with 8 participating centres in Norway. We will include patients with the diagnosis of early infections (within 4 weeks post operatively)after hi...
Eligibility Criteria
Inclusion
- Prosthetic joint infections category 2 or 3 (early post.op infections within 4 weeks).
- Diagnosis of staphylococci.
- Clinically and radiographically stable implants kept in place after revision.
Exclusion
- Infection with other microorganisms than staphylococci.
- Less than 2 years of expected survival.
- Predictable inability to comply with the treatment and/or follow-up visits.
- Contraindication to the use of study medication including acute or chronic liver disease.
- Lack of written consent.
- Fertile women.
- Patients taking less than 80% of the study medication.
Key Trial Info
Start Date :
April 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2014
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00423982
Start Date
April 1 2006
End Date
December 1 2014
Last Update
June 27 2013
Active Locations (8)
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1
Buskerud Central Hospital
Drammen, Norway, 3004
2
Elverum Hospital
Elverum, Norway, 2408
3
Martina Hansen Hospital
Gjettum, Norway, 1346
4
Ringerike Hospital
Hønefoss, Norway, 3504