Status:
COMPLETED
Endothelin-Receptor Blockade in Coronary Heart Disease
Lead Sponsor:
Medical University of Vienna
Conditions:
Coronary Vessels
Endothelins
Eligibility:
All Genders
19+ years
Phase:
PHASE1
Brief Summary
Endothelin is a hormon that causes acute and chronic narrowing of heart vessels. The purpose of this study is to assess whether suppression of this activity by using two types of receptor antagonists ...
Detailed Description
Endothelin (ET) is the most potent vasoconstrictor known and plays a major role in the development of coronary artery disease as well as in acute vasoconstriction. This effect is mainly mediated by th...
Eligibility Criteria
Inclusion
- coronary artey disease
- stable angina pectoris
- male and post-menopausal female patients
- age above 19 years
- able and willing to conform to the requirements of the study
- provided written informed consent
Exclusion
- severe focal coronary stenosis
- visually calcified stenosis
- aorto-ostial lesion location and unprotected left main stenosis
- pre-menopausal female patients
- diabetes mellitus
- unstable angina pectoris and/or acute Q-wave myocardial infarctaion within the past 72 hours
- current vasoactive medication
- previous percutaneous transluminal revascularization at the site of the target lesion
- lesion which has extremely angulated segments \>90%
- vessel with escessive tortuosity of the proximal segment
- severe hypotension
- severely reduced left ventricular function
- severe carotid stenosis
- patients with pace maker
- patients with elevated liver enzymes
- patients simultaneously participating in another device or drug study
- inability of unwillingness to comply with the study protocol
Key Trial Info
Start Date :
May 1 2003
Trial Type :
INTERVENTIONAL
End Date :
August 1 2006
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT00427232
Start Date
May 1 2003
End Date
August 1 2006
Last Update
January 26 2007
Active Locations (1)
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1
Dept. of Internal Medicine II, Medical University of Vienna
Vienna, Vienna, Austria, A-1090