Status:
COMPLETED
Azathioprine or Mycophenolate Mofetil for Bullous Pemphigoid
Lead Sponsor:
University Hospital Muenster
Collaborating Sponsors:
Hoffmann-La Roche
Conditions:
Bullous Pemphigoid
Eligibility:
All Genders
18-90 years
Phase:
PHASE2
Brief Summary
To investigate the safety and efficacy of oral methylprednisolone combined with azathioprine or mycophenolate mofetil for the treatment of bullous pemphigoid.
Detailed Description
This multicenter randomized, non-blinded clinical trial compared two parallel groups of patients with bullous pemphigoid treated with oral methylprednisolone in combination with either azathioprine or...
Eligibility Criteria
Inclusion
- clinical lesions suggestive of bullous pemphigoid
- subepidermal blistering upon histological analysis of skin biopsies
- linear deposition of IgG and C3 along the dermo-epidermal junction
- deposition of autoantibodies at the blister roof upon split-skin analysis
Exclusion
- treatment with oral or topical corticosteroids, and other immunosuppressive drugs during the previous four weeks
Key Trial Info
Start Date :
October 1 1997
Trial Type :
INTERVENTIONAL
End Date :
October 1 2000
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT00431119
Start Date
October 1 1997
End Date
October 1 2000
Last Update
February 5 2007
Active Locations (11)
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1
Dermatology, Univ. of Cologne
Cologne, Germany, 50931
2
Dermatology, Univ. of Dresden
Dresden, Germany, 01307
3
Dermatology, Univ. of Duesseldorf
Düsseldorf, Germany, 40225
4
Dermatology, Univ. of Goettingen
Göttingen, Germany, 37075