Status:
COMPLETED
Brain Activation Patterns in Schizophrenia After Computerized Cognitive Skills Training
Lead Sponsor:
Manhattan Psychiatric Center
Collaborating Sponsors:
Nathan Kline Institute for Psychiatric Research
Conditions:
Schizophrenia
Eligibility:
MALE
18-55 years
Phase:
NA
Brief Summary
This project is a novel exploratory research project to investigate changes in activation patterns of the dorsolateral prefrontal cortex (DLPFC) in inpatients with schizophrenia who received a 12-week...
Detailed Description
Abnormalities in the domains of attention, working memory (WM) and information processing are important features of schizophrenia. There is growing literature that cognitive remediation therapy (CRT) ...
Eligibility Criteria
Inclusion
- Inpatient status
- Age 18 - 55
- Male gender (females are enrolled but will not be scanned)
- DSM-IV diagnosis of schizophrenia (all subtypes) and schizoaffective disorder
- illness duration \> 5 years
- MMSE score \> 24 (inclusive) at screening
- Stable dose of oral atypical antipsychotic for at least 4 weeks prior to study entry
- Total PANSS score \> 60 at screening
- Capacity and willingness to give written informed consent
- Patients deemed not ready to be discharged within the next 12 weeks
Exclusion
- Inability to read or speak English
- Documented disease of the central nervous system
- History of intellectual impairment pre-dating onset of symptoms of psychosis (e.g. mental retardation)
- Clinically significant or unstable cardiovascular, renal, hepatic, gastrointestinal, pulmonary, or hematological conditions; HIV positive
- Any medical condition rendering the subject unable to receive an fMRI scan
Key Trial Info
Start Date :
September 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2008
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT00431223
Start Date
September 1 2006
End Date
September 1 2008
Last Update
October 6 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Manhattan Psychiatric Center
New York, New York, United States, 10035