Status:
COMPLETED
Combination Methotrexate and Infliximab
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Ankylosing Spondylitis
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
Combination Methotrexate and Infliximab:Influence of immunogenicity on the efficacy of infliximab in patients with Ankylosing Spondylitis.
Detailed Description
Forty consecutive patients will be recruited from the rheumatology clinic of the Prince of Wales Hospital with AS meeting the modified New York criteria with active disease as defined (see below). The...
Eligibility Criteria
Inclusion
- Fulfilled the AS:meeting the modified New York criteria
- Active disease despite NSAID treatment defined as:
- Spinal inflammation ≧ 30 and a score of 30 on at least two of the other three domains
- Back pain
- Patient global assessment of disease activity
- Physical function
- Informed consent
Exclusion
- Complete ankylosis of the spine
- On sulphasalazine
- Previous use of TNF inhibitors
- Multiple use of NSAIDS
- Prednisolone \> 10mg/day
- Changes of NSAIDS or dose of prednisolone within 2 weeks of baseline
- Little or no ability for self-care
- Received intra-articular,intramuscular, or intravenous corticosteroids in the 4 weeks before screening
- Infected joint prosthesis during the previous 5 years
- Serious infections, such as hepatitis, pneumonia, pyelonephritis in the previous 3 months
- Any chronic infectious disease such as renal infection, chest infection with bronchiectasis or sinusitis
- Active tuberculosis requiring treatment within the previous 3 years
- Opportunistic infections such as herpes zoster within the previous 2 months
- Any evidence of active cytomegalovirus; active Pneumocystis carinii; or drug-resistant atypical mycobacterial infection
- Known hypersensitivity to murine proteins
- Current signs or symptoms of severe,progressive,or uncontrolled renal, hepatic, haematological, gastrointestinal, endocrine, pulmonary, cardiac, neurological, or cerebral disease
- A history of lymphoproliferative disease including lymphoma or signs suggestive of disease, such as lymphadenopathy of unusual size or location (ie,lymph nodes in the posterior triangle or the neck, infraclavicular epitrochlear, or periaortic areas); splenomegaly;
- Any known malignant disease except basal cell carcinoma currently or in the past 5 years.
- A hemoglobin level \< 8.5 gm/dl, a white blood cell count \< 3.5 × 10\^9/liter, a platelet count \< 100 × 10\^9/liter, a serum creatinine level \> 150 µmol/l, serum transaminase levels 1.25 times the upper limit of normal, or alkaline phosphatase levels \> 2 times the upper limit of normal.
Key Trial Info
Start Date :
February 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2006
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT00432432
Start Date
February 1 2005
End Date
October 1 2006
Last Update
February 13 2012
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