Status:
COMPLETED
Influence of nCPAP on Metabolic Consequences Associated With OSAS
Lead Sponsor:
Federal University of São Paulo
Conditions:
Obstructive Sleep Apnea Syndrome
Obesity
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Context: Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular morbidity. Recurrent episodes of occlusion of upper airways during sleep result in hormonal changes that may predispo...
Detailed Description
Background: There is evidence that obstructive sleep apnea syndrome (OSAS) increases the risk of cardiovascular events. Sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis activat...
Eligibility Criteria
Inclusion
- Aged from 18 to 65 years
- Body mass index between 35-60 who were submitted to polysomnography
Exclusion
- History of smoking
- Sleep apnea treatment
- Cardiovascular disease
- Malignancies tumor
- Thyroid disorders
- Depression
- Subjects with known diabetes mellitus on medications
- Chronic renal or hepatic failure
- On hormonal replacement therapy, as well as use of medication that could potentially affect steroid hormone or cytokines secretion (alcohol, psychotropics, steroids, sympathomimetics, beta-blockers).
Key Trial Info
Start Date :
October 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2006
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00435643
Start Date
October 1 2004
End Date
March 1 2006
Last Update
November 20 2007
Active Locations (1)
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1
Universidade Federal de Sao Paulo
São Paulo, São Paulo, Brazil, 04023-062