Status:
COMPLETED
Evaluation of Three Continuation Therapies After ECT Concerning Efficacy and Cognition in Severly Depressed Patients
Lead Sponsor:
Charite University, Berlin, Germany
Collaborating Sponsors:
German Research Foundation
Conditions:
Depression
Major Depression
Eligibility:
All Genders
18-90 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to evaluate three different continuation treatments after acute ECT concerning efficacy and impact on cognition in severly depressed patients.
Detailed Description
BACKGROUND While electroconvulsive therapy (ECT) in major depression is effective, high relapse rates and cognitive effects limit its long-term use. Continuation treatment after ECT with combinations ...
Eligibility Criteria
Inclusion
- Major depressive episode (unipolar)
- Response to acute ECT (at least 50% reduction in HAMD)
- Capacity to consent
- Sufficient comprehension of the German language
Exclusion
- Schizophrenia, schizoaffective disorder, or other psychosis
- Amnestic disorder, dementia, or delirium
- Pregnancy
- Epilepsy
- Current alcohol or substance abuse or dependence
- CNS disease or brain injury not associated with psychotropic drug exposure
- ECT in the past 3 months
- Acute suicidality
- Judiciary hospitalization
Key Trial Info
Start Date :
March 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00437385
Start Date
March 1 2005
End Date
March 1 2011
Last Update
November 10 2011
Active Locations (1)
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1
Department of Psychiatry, Charité University Medicine, Campus Benjamin Franklin, Berlin, Germany
Berlin, State of Berlin, Germany, 14050