Status:
COMPLETED
Dexamethasone for the Prophylaxis of Pain Flare Study
Lead Sponsor:
Sunnybrook Health Sciences Centre
Conditions:
Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Radiation treatment is often recommended as a safe and quick treatment that gives most people good relief from bone pain within a couple of weeks. However, some people can experience a short episode o...
Detailed Description
Of all people diagnosed with cancer, 25% will have their cancer come back and spread to the bones. This often results in significant pain and suffering. Radiation treatment is often recommended as a s...
Eligibility Criteria
Inclusion
- Documented bone metastases by radiological imaging
- Patients at least 18 years of age
- Written consent
- KPS ≥ 40
- Baseline worst pain at the planned radiated bony metastatic site ≥ 2
- Patient able to inform the pain score at the planned radiated bony metastatic site
Exclusion
- Concurrent use of any corticosteroid medication other than topical or inhaled preparations
- Medical contraindications to corticosteroids such as diabetes mellitus, uncontrolled hypertension or active peptic ulcer
- Pathological fracture of the irradiated extremity
- Spinal cord compression
- Language barrier
- Immediate change in regular analgesic medication. If the oncologist thinks the patient is not receiving adequate analgesic, we recommend the oncologist to increase the analgesic first to stabilize ot lessen the pain before recruiting the patient to this study
Key Trial Info
Start Date :
February 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
61 Patients enrolled
Trial Details
Trial ID
NCT00438828
Start Date
February 1 2007
End Date
July 1 2011
Last Update
November 19 2014
Active Locations (1)
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1
Odette Cancer Centre
Toronto, Ontario, Canada, M4N 3M5