Status:
UNKNOWN
Treatment Resistant Depression and Obstructive Sleep Apnea, Effect of Continuous Positive Airway Pressure (CPAP)
Lead Sponsor:
Queen's University
Conditions:
Depression
Sleep Apnea, Obstructive
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of the study is to determine the effect on mood and anxiety symptoms of adding CPAP to the psychiatric treatment of patients with TRD (treatment resistant depression) and associated OSA (o...
Detailed Description
Primary objective: What is the effect on mood and anxiety symptoms of adding CPAP to the psychiatric treatment of patients with TRD and associated OSA? Secondary objectives: 1. How common is co-mor...
Eligibility Criteria
Inclusion
- Patients with TRD.
- Males and females between the ages of 18 and 65 years who agree to take part and sign the Informed Consent will be invited to participate in the study.
- Patients with co-morbid Dysthymic Disorder, Generalized Anxiety Disorder or Social Anxiety Disorder may be included in the study.
Exclusion
- Patients with uncontrolled medical illnesses will not be permitted to participate.
- Patients with a history of current or Bipolar Disorder, Schizophrenia, Panic Disorder, Obsessive-Compulsive Disorder or Anorexia Nervosa.
- Head injury patients resulting in loss of consciousness for more than 10 minutes.
- Patients with epilepsy or severe personality disorders who, at the judgment of the investigators, are not appropriate candidates for the study, will be excluded.
- Patients who do not have the mental or physical capacity to apply the CPAP interface and to plug in and switch on an auto CPAP unit at home will be excluded.
- Blind and/or deaf patients will be excluded.
- Patients who initially decline an offer of CPAP treatment for OSA, and those who prefer conservative treatment options (weight loss, avoidance of alcohol and sedatives) will be excluded.
- Patients with severe claustrophobia, who cannot tolerate any CPAP interface, will be excluded.
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2019
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00441636
Start Date
March 1 2007
End Date
December 1 2019
Last Update
April 30 2018
Active Locations (1)
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1
Providence Continuing Care Centre, Mental Health Services
Kingston, Ontario, Canada, K7L4X3