Status:
COMPLETED
24-hour Intraocular Pressure Control With Travoprost/Timolol Fixed Combination Versus Travoprost
Lead Sponsor:
Aristotle University Of Thessaloniki
Collaborating Sponsors:
Alcon Research
Conditions:
Glaucoma
Eligibility:
All Genders
29-81 years
Phase:
PHASE4
Brief Summary
This 8-week, crossover study will compare the quality of 24-hour IOP control with TTFC versus travoprost when both medications are dosed in the evening. Such a crossover comparison may determine the r...
Eligibility Criteria
Inclusion
- Consecutive adults with primary open-angle glaucoma (POAG) who exhibit a mean untreated IOP greater than 23 m Hg at baseline (10:00).
- Patient has POAG and is older than 29 years
- The IOP without treatment is greater than 23 mm Hg and lower than 38 mm Hg at baseline (2 readings at 10:00)
- Patient can be safely washed out without risk for significant deterioration
- Distance best corrected Snellen visual acuity better than 1/10
- Patient can understand the instructions and comply to medications
- Open normal appearing angles
Exclusion
- Contraindications to prostaglandins or β-blockers
- History of lack of response (\<10% reduction) to any medication
- Female of childbearing potential or lactating mother
- History of trauma, inflammation, surgery, past use of steroids (within 2 months), severe dry eyes and use of contact lenses
- Sign of ocular infection, except blepharitis, corneal abnormality that may affect IOP measurements etc
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00444184
Start Date
March 1 2007
End Date
January 1 2008
Last Update
May 12 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Glaucoma Unit, 1st University Department of Ophthalmology
Thessaloniki, Greece, 546 36