Status:
COMPLETED
CPAP Versus NPPV in ACPE
Lead Sponsor:
Ospedale S. Giovanni Bosco
Conditions:
Pulmonary Edema
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
To assess the intubation rate in patients affected by severe cardiogenic pulmonary edema treated with CPAP or NPPV.
Detailed Description
Background Although non-invasive ventilation has shown to be an effective treatment for acute cardiogenic pulmonary oedema (ACPO), literature still lacks of multi-centre randomised prospective studies...
Eligibility Criteria
Inclusion
- rapid onset of the symptoms
- severe dyspnoea at rest
- respiratory rate \> 30 breath per minute
- use of accessory respiratory muscles
- PaO2/FiO2 \< 200, radiological findings of ACPE
Exclusion
- ST elevation myocardial infarction
- hemodynamic instability (systolic arterial pressure \< 90 mmHg
- need for immediate endotracheal intubation (respiratory arrest, bradypnea
- inability to protect the airways, impaired sensorium (agitation or unconsciousness
- inability to clear secretions, respiratory tract infections
- chronic obstructive pulmonary disease (COPD) exacerbation, chronic respiratory failure necessitating long-term oxygen therapy
- pulmonary embolism, pneumonia, recent oesophageal-gastric surgery
- gastrointestinal bleeding
- facial deformities
- haematological malignancy or cancer with Eastern Cooperative Oncology Group (ECOG) performance status ≥ 2.
Key Trial Info
Start Date :
July 1 2002
Trial Type :
INTERVENTIONAL
End Date :
May 1 2005
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00446498
Start Date
July 1 2002
End Date
May 1 2005
Last Update
April 3 2007
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Ospedale San Giovanni Bosco Medicina d'Urgenza
Torino, Italy, 10154