Status:
COMPLETED
Brain Activity in People With Functional Movement Disorders
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Functional Movement Disorders
Eligibility:
All Genders
18-65 years
Brief Summary
This study will use functional MRI (fMRI, a technique that shows what areas of the brain are active when performing different mental tasks), to examine how the brain in people with functional movement...
Detailed Description
OBJECTIVE The purpose of this study is to utilize functional MRI (fMRI) to identify structural brain regions and activation patterns involved in deception in order to determine whether illness decept...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- PATIENTS:
- Age 18 to 65
- Subjects willing to abstain from caffeine or alcohol for 48 hours prior to the fMRI scanning
- Diagnosis of a functional movement disorder confirmed by a study investigator
- HEALTHY VOLUNTEERS:
- \- Age 18 to 65
- EXCLUSION CRITERIA:
- Subjects with any abnormal findings on neurological exam consistent with an organic disorder
- Subjects with a positive urine pregnancy test
- Subjects with a positive urine drug screen
- Subjects who are pregnant
- Subjects with any finding on the MRI safety questionnaire which prevents them from safely undergoing an MRI scan
- Subjects with metallic dental fillings which are likely to enhance MRI artifacts
- Subjects with any history of dementia, brain tumor, stroke, head trauma or a vascular malformation as obtained by history or from imaging studies
- Subjects with moderate to severe brain atrophy on imaging studies, as assessed by a study investigator
- Subjects with any history of a severe medical condition, such as cardiovascular disease, which would prevent them from lying flat for up to 120 minutes
- Subjects without the capacity to give informed consent
- Subjects with claustrophobia or other restrictions which prevent them from undergoing a scan in a confined space for up to 120 minutes
- Subjects using beta-blocker medications or other chronotropes which may inhibit the cardiac responsivity
- Patient whose movement frequency and severity prevents them from undergoing MRI safely and effectively for the purposes of data collection
- Patient with a pending medical-legal case
- Subjects with suicidal ideation
Exclusion
Key Trial Info
Start Date :
March 8 2007
Trial Type :
OBSERVATIONAL
End Date :
August 5 2008
Estimated Enrollment :
65 Patients enrolled
Trial Details
Trial ID
NCT00448084
Start Date
March 8 2007
End Date
August 5 2008
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892