Status:
COMPLETED
Exhaled Breath Condensate (EBC) Assessment in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
18-90 years
Brief Summary
This study aimed to assess airway inflammation in patients during the course of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) by serial analyses of their exhaled breath condens...
Detailed Description
Subject recruitment Patients who had been admitted to the Prince of Wales Hospital with AECOPD were recruited for this study. Subjects with pneumonic changes on the chest radiographs were excluded. A...
Eligibility Criteria
Inclusion
- Patients who had been admitted to the Prince of Wales Hospital with AECOPD were recruited for this study. AECOPD was defined when a patient with background COPD according to the GOLD guideline presented with at least two of the following major symptoms (increased dyspnoea, increased sputum purulence, increased sputum volume) or one major and one minor symptom (nasal discharge/congestion, wheeze, sore throat, cough) for at least two consecutive days.
- Age and sex-matched COPD subjects at stable state (without AECOPD for at least 10 weeks) and healthy, non-smoking subjects were recruited as controls. Current smokers (defined as cigarette smoking in the last 6 months) were excluded from this study.
Exclusion
- Subjects with pneumonic changes on the chest radiographs were excluded.
- Current smokers (defined as cigarette smoking in the last 6 months) were excluded from this study.
Key Trial Info
Start Date :
February 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00448500
Start Date
February 1 2006
End Date
January 1 2008
Last Update
May 9 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Prince of Wales Hospital
Hong Kong, Hong Kong