Status:
COMPLETED
S0424 - Carcinogens in Lung Tissue From Smokers (Closed to Entry as of 7/15/07) and Non-Smokers With Newly Diagnosed Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer
Lead Sponsor:
SWOG Cancer Research Network
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Lung Cancer
Eligibility:
All Genders
18-120 years
Brief Summary
RATIONALE: Studying samples of blood and tissue from smokers (closed to entry as of 7/15/07) and non-smokers with cancer in the laboratory may help doctors learn more about changes that occur in DNA a...
Detailed Description
OBJECTIVES: * Assess lung tissue from patients with stage I, stage II, stage IIIA, or stage IIIB non-small cell lung cancer for specific tobacco smoke carcinogens (including polycyclic aromatic hydro...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically confirmed non-small cell lung cancer
- Stage I, II, IIIA, or IIIB (T4 or N3) disease
- No malignant pleural effusion; if pleural fluid is present, 1 of the following criteria must be met:
- Benign pleural fluid
- Pleural fluid is due to prior thoracotomy
- Pleural fluid is deemed too small to safely tap
- No diagnosis by cytology alone
- Newly diagnosed disease
- Must have tumor blocks/slides available and must be willing to provide tissue samples
- Prior smoking history meeting 1 of the following criteria:
- Never smoker, defined as \< 100 cigarettes in lifetime
- Former smoker, defined as no smoking for ≥ 1 year
- Current smoker, defined as all others (closed to accrual as of 7/15/07)
- No pericardial effusions
- PATIENT CHARACTERISTICS:
- No other prior malignancy except for 1 of the following:
- Adequately treated basal cell or squamous cell skin cancer
- In situ cervical cancer
- Other cancer for which the patient has been disease free for five years
- PRIOR CONCURRENT THERAPY:
- No prior chemotherapy or radiotherapy
- Concurrent participation in therapeutic trials allowed
Exclusion
Key Trial Info
Start Date :
October 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
981 Patients enrolled
Trial Details
Trial ID
NCT00450281
Start Date
October 1 2005
End Date
July 1 2012
Last Update
October 26 2015
Active Locations (405)
Enter a location and click search to find clinical trials sorted by distance.
1
Providence Cancer Center
Anchorage, Alaska, United States, 99508
2
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, United States, 85724-5024
3
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Fort Smith, Arkansas, United States, 72903
4
Kaiser Permanente - Deer Valley
Antioch, California, United States, 94531