Status:
UNKNOWN
Dexamethasone and the Prevention of Post-Extubation Airway Obstruction in Adults
Lead Sponsor:
Mackay Memorial Hospital
Conditions:
Airway Obstruction
Eligibility:
All Genders
18-95 years
Phase:
PHASE2
Brief Summary
Laryngotracheal injury related to intubation may cause narrowing of the airway due to edema of the glottis. Post-extubation airway frequently necessitating re-intubation and resulting in the prolongat...
Detailed Description
Materials and methods Patients The current study included patients admitted to the adult medical ICU of the Mackay Memorial Medical Center from 1 October 2004 and 1 July 2007 and who met the inclusion...
Eligibility Criteria
Inclusion
- All patients were \> 18 years of age and met the following weaning criteria:
- Temperature ≤ 38°C for \> 8 hours,
- Discontinuous use of sedatives,
- Heart rate ≥ 70 and ≤ 130 /min,
- Systolic blood pressure (SBP) ≥ 80 mm Hg in the absence of vasopressors,
- Fraction of inspired oxygen (FiO2) ≤ 0.6, PaO2 ≥ 60, and partial pressure of oxygen (PaO2)/FiO2 ratio \> 200,
- Positive end-expiratory pressure (PEEP) ≤ 5 cm H2O,
- Rapid and shallow ratio of frequency to tidal volume (f/VT ≤ 105),
- Minute ventilation ≤ 15 L/min, and
- pH ≥ 7.3. Supplemental oxygen was continued to maintain an oxygen saturation \> 95% as measured by a pulse oximeter.
Exclusion
- The need for more than one tracheal intubation during the hospital stay,
- Unstable hemodynamics (i.e., a mean SBP \< 90 mm Hg, a SBP decrease \> 40 mm Hg, or a mean arterial pressure \[MAP\] \< 70 mm Hg),
- Profound recalcitrant hypoxemia (i.e., PaO2 \< 60 mm Hg with a FiO2 \> 0.50), or
- Administration of corticosteroids 7 days prior to extubation.
Key Trial Info
Start Date :
October 1 2004
Trial Type :
INTERVENTIONAL
End Date :
July 1 2007
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT00452062
Start Date
October 1 2004
End Date
July 1 2007
Last Update
March 26 2007
Active Locations (1)
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1
Mackay Memorial Hospital
Taipei, Taipei, Taiwan, 104