Status:
UNKNOWN
Esomeprazole Treatment for Patients With Lymphocytic Gastritis
Lead Sponsor:
Technische Universität Dresden
Conditions:
Lymphocytic Gastritis
Eligibility:
All Genders
18-80 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine whether treatment with esomeprazole alone is able to heal patients with lymphocytic gastritis
Detailed Description
Recently, a placebo controlled trial of our group has shown that H. pylori eradication therapy consisting of omeprazole 20 mg bid, clarithromycin 500 mg bid, amoxicillin 1000 mg bid for seven days lea...
Eligibility Criteria
Inclusion
- Histologically proven lymphocytic gastritis (IEL \> 25/100)
- Male or female aged 18 years or older
- Signed and written informed consent
Exclusion
- Regular NSAID or aspirin intake
- Concomitant medication with antibiotics, bismuth subsalicylate, aminosalicylates
- Regular PPI therapy
- Treatment with ketoconazole or other CYP3A inhibitors
- previous surgery of the stomach
- known or suspected hypersensitivity to esomeprazole
- Malignant diseases
- Concomitant severe diseases
- Pregnancy or lactation
- Contraindication to take biopsies (Quick \< 50%, PTT \> 50 s, thrombocytes \< 100.000/mm3)
Key Trial Info
Start Date :
February 1 2007
Trial Type :
INTERVENTIONAL
End Date :
December 1 2009
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00455754
Start Date
February 1 2007
End Date
December 1 2009
Last Update
April 4 2007
Active Locations (1)
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1
Medical Department I, University Hospital Carl Gustav Carus, Technical University
Dresden, Germany, 01307