Status:
UNKNOWN
Effect of Clopidogrel Loading and Risk of PCI
Lead Sponsor:
University Heart Center Freiburg - Bad Krozingen
Conditions:
Coronary Artery Disease
Drug Resistance
Eligibility:
All Genders
18+ years
Brief Summary
This study is a prospective, single-center evaluation of the impact of the variability in platelet response after loading with clopidogrel on the peri-interventional risk of patients undergoing PCI.
Detailed Description
Background: Platelet responses after loading with clopidogrel are highly variable. The impact of this variability on the peri-interventional risk of patients undergoing PCI has not been investigated p...
Eligibility Criteria
Inclusion
- Patients undergoing elective coronary stenting
- Pretreatment with a bolus dose of 600mg of clopidogrel prior to coronary stent implantation
- Pretreatment with aspirin ≥ 100 mg per day for at least 7 days
- Age \> 18 years
- Written consent
Exclusion
- Troponin T on admission \> 0.03 ng/mL
- Myocardial infarction or fibrinolytic therapy within the previous 14 days
- Cardiogenic shock
- Contraindication for aspirin or clopidogrel
- Oral anticoagulation
- Pretreatment with heparin or a thienopyridine within the previous 14 days
- Use of a GP IIb/IIIa-receptor antagonist during PCI
- Platelet count \< 100.000/µl
- Severe disorders of the coagulation system
- Severe impairment of liver or kidney function
- Cancer
Key Trial Info
Start Date :
March 1 2003
Trial Type :
OBSERVATIONAL
End Date :
December 1 2007
Estimated Enrollment :
800 Patients enrolled
Trial Details
Trial ID
NCT00457236
Start Date
March 1 2003
End Date
December 1 2007
Last Update
April 6 2007
Active Locations (1)
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1
Heart Center Bad Krozingen
Bad Krozingen, Germany, 79189