Status:
TERMINATED
Use of Dexmedetomidine to Facilitate Extubation in Surgical ICU Patients Who Failed Previous Weaning Attempts
Lead Sponsor:
University of California, San Francisco
Conditions:
Intubation; Difficult
Respiration Disorders
Eligibility:
All Genders
18-69 years
Phase:
NA
Brief Summary
Mechanical ventilation commonly is associated with patient agitation requiring sedation to alleviate discomfort and reduce excessive central respiratory drive. Upon recovery from acute respiratory fai...
Detailed Description
Sixty patients who are admitted to the surgical intensive care unit (ICU) at San Francisco General Hospital will be referred to the investigators for enrollment into a prospective, unblinded, randomiz...
Eligibility Criteria
Inclusion
- Age less than 70 years old
- Normothermia (36.5 degrees centigrade)
- Normal sinus rhythm
- Hemodynamically stable (systolic blood pressure \[SBP\] \> 110 mmHg)
- Ejection fraction (EF) \> 40%/absence of congestive heart failure (CHF)
- Cardiac index \> 2.5 L/min/m2
- Minimal inotropic support (\< 3 mcg/kg/min dobutamine)
- Adequate coagulation profile
- Adequate urine output (\> 100 ml/hr)
- Primary service and critical care physician agreement
Exclusion
- Prior use of clonidine or alpha-antagonists
- Prior history of intravenous drug abuse (IVDA) or alcohol abuse (ETOH)
- Evidence of heart block
- Difficulty with oxygenation/ventilation
- Renal or hepatic insufficiency
- Pregnant (positive urine or serum pregnancy test upon admission)
- Patient received dexmedetomidine \> 24 hours
Key Trial Info
Start Date :
November 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT00464490
Start Date
November 1 2007
End Date
December 1 2012
Last Update
October 31 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of California, San Francisco
San Francisco, California, United States, 94110