Status:
COMPLETED
Protective Ventilation With Carbon Dioxide (CO2) -Removal Technique in Patients With Adult Respiratory Distress Syndrome (ARDS)
Lead Sponsor:
University of Turin, Italy
Collaborating Sponsors:
Regione Piemonte
Conditions:
Adult Respiratory Distress Syndrome
Eligibility:
All Genders
18-85 years
Phase:
PHASE3
Brief Summary
30% of ARDS patients ventilated according to NIH protocol presents morphological (CT) and functional (Stress Index\>1) conditions of hyperinflation even with Plateau pressure (Pplat) \< 30 cmH2O; valu...
Detailed Description
Aim of the study was to verify the efficacy of CO2-removal technique in reducing Vt and consequently Pplat to obtain a Stress Index value equal to 1.
Eligibility Criteria
Inclusion
- ARDS patients with Pplat \>= 26 during NIH protective ventilation protocol
Exclusion
- Age \< 18 years
- Brain injury and patients with intracranial pressure \> 20 mmHg
- Pregnancy
- Immunodepressed patients
- Patients already enrolled in other trials
- Renal replacement therapy
- BMI \> 40
- Contraindication anticoagulation treatment
- Morphological abnormalities of femoral veins
- NYHA III-IV
- Burns BSA\>30%
- Hepatic failure (grade C Child)
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2008
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00465309
Start Date
April 1 2007
End Date
November 1 2008
Last Update
January 12 2009
Active Locations (2)
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1
University of Turin, Department of Anesthesia and Intensive Care Medicine,S. G. Battista Hospital
Turin, Turin, Italy, 10126
2
University of Turin, Department of Anesthesia and Intensive Care Medicine
Turin, Italy, 10126