Status:
TERMINATED
Protein Biomarker in Hepatocellular Carcinoma
Lead Sponsor:
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Collaborating Sponsors:
Singapore Cancer Society
Conditions:
Normal Volunteers
Hepatitis
Eligibility:
All Genders
18+ years
Brief Summary
Hepatocellular carcinoma (HCC) is the fifth commonest cancer in the world with poor prognosis, as the annual mortality is almost equivalent to the incidence. This is mainly due to late diagnosis and c...
Detailed Description
Up to 40% of HCC patients have normal AFP. Moreover, AFP can also be elevated in patients with cirrhosis or exacerbation of chronic hepatitis. Prospective studies evaluating the value of AFP in HCC su...
Eligibility Criteria
Inclusion
- Group A: Normal volunteers without any history of liver disease and with normal liver functions test (LFT), including total protein/Albumin, LDH, ALT, AST, GGT, total bilirubin, direct and indirect bilirubin and do not belong to group B. Volunteers will be screened using questionnaires. Those deemed suitable will then be asked to have the blood test done. All blood tests are done free of charge to subjects.
- Group B: Hepatitis B or C carriers with normal liver functions.
- Group C: Hepatitis B or C carriers with abnormal liver functions.
- Group D: Liver cirrhosis, proven by liver biopsy or on clinical evidences, such as varices on CT scan indicative of portal hypertension.
- Group E: HCC patients with resection.
- Group F: Unresectable HCC patients with treatment.
- Group G: HCC patients with active malignant disease and only palliative care are offered.
- Signed Informed Consent
- ≥ 18 years of age
- In this trial, diagnosis of HCC is established with either (a) known hepatitis B or C carrier, and space occupying lesion(s) in the liver and AFP \> 400ng/ml or (b) cytological or histological confirmation by biopsy
Exclusion
- There is no exclusion criteria
Key Trial Info
Start Date :
June 20 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 14 2013
Estimated Enrollment :
211 Patients enrolled
Trial Details
Trial ID
NCT00465842
Start Date
June 20 2006
End Date
August 14 2013
Last Update
February 15 2019
Active Locations (1)
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1
Johns Hopkins Singapore International Medical Center
Singapore, Singapore, 308433