Status:
TERMINATED
Study of Weekly Paclitaxel, Carboplatin and Irinotecan to Treat Lung Cancer
Lead Sponsor:
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Conditions:
Lung Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Evaluate the efficacy and toxicity of the weekly combination chemotherapy of Paclitaxel, Carboplatin and Irinotecan in Stage IIIb and IV NSCLC with malignant pleural effusion
Detailed Description
Lung cancer is the leading cancer death in many countries of the world including Singapore. Non-small cell lung cancer (NSCLC) consists of 80-85% of lung cancers, and is a major health problem. The ma...
Eligibility Criteria
Inclusion
- Histological or cytological diagnosis of non-small cell lung cancer.
- Malignant pleural effusion proven by cytological examination.
- Patient must have stage IIIB or IV disease with malignant pleural effusion.
- We plan to recruit 16 patients who have smoked cigarettes of at least 20 pack per year, 16 patients who do not smoke but have been exposed to second hand smoking by living with a person who has smoked 20 pack per year cigarette in the same household and 16 patients who are non-smokers (never smoked) and no second hand smoking exposure in the same household. The accrual will be stopped once the number of patients is reached in each group.
- ECOG PS 0, 1 or 2.
- Measurable disease (in addition to malignant pleural effusion).
- No prior chemotherapy for metastatic or recurrent disease. Patient may have surgery or radiation or combined chemoradiation, or neoadjuvant chemotherapy at primary diagnosis. This kind of chemotherapy will not be counted as patient has had prior chemotherapy for metastatic or recurrent NSCLC.
- WBC \> 3500/uL and ANC \> 2,000/uL, platelet \> 100,000/uL AST/ALT \< 3 X UNL, bilirubin \< 1.5 mg/dL ( or \< 35 uM), creatinine \< 1.5 mg/dL (or \< 125uM for men and 90uM for women).
- Age \> 18
- No history of congestive heart failure, myocardial infarction or life-threatening arrhythmia (such as ventricular tachycardia, supraventricular tachycardia, brachycardia \< 40/min or atrial fibrillation or flutter with ventricular rate \> 150/min) within 6 months of entry.
- Signed informed consent
- Negative mammogram and ovaries examination by CT scans and no history of breast cancer or ovarian cancer in female patients.
- Negative pregnancy test in female menstruating patient within one week of starting chemotherapy and use of effective contraceptive methods during study.
- Patients with brain metastasis will be eligible provided their neurological abnormality is stable or improved after whole brain radiation, stereostatic radiosurgery or gamma knife treatment and/or dexamethasone for 3 weeks and patients fulfil all other eligibility criteria.
Exclusion
- ECOG performance status 3 or worse.
- Any prior chemotherapy regimen for metastatic or recurrent diseases.
- No measurable disease, even after drainage of pleural effusion.
- ANC \< 1,999/uL or Bilirubin \> 1.5 mg/dL (or \> 35uM)
- Plt \< 100,000/uL or
- ALT/AST \> 3 x UNL
- Creatinine \> 1.5mg/dL (or \> 125uM)
- Patient has history of congestive heart failure, myocardial infarction or life-threatening arrhythmia (such as ventricular tachycardia, supraventricular tachycardia, atrial fibrillation/flutter with ventricular rate \> 150/min or bradycardia \< 40/min) within 6 months before entry.
- Prior history of breast cancer or ovarian cancer in female patients or any cancer except cured cervical carcinoma in-situ or skin cancer.
- Fasting blood sugar \> 200 mg/dL (\> 14uM) except in patients on dexamethasone for brain metastases.
Key Trial Info
Start Date :
May 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2014
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT00465907
Start Date
May 1 2003
End Date
February 1 2014
Last Update
February 11 2019
Active Locations (1)
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1
Johns Hopkins Singapore International Medical Center
Singapore, Singapore, 308433