Status:
TERMINATED
Defining the Role of Insulin Resistance in 'Idiopathic' Dilated Cardiomyopathy
Lead Sponsor:
Stanford University
Conditions:
Dilated Cardiomyopathy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study will investigate the effects of rosiglitazone, a medicine commonly used to treat type 2 diabetes, on the utilization of glucose by the heart in patients with heart failure which is not due ...
Detailed Description
Nondiabetic patients with nonischemic cardiomyopathy who are insulin-resistance or insulin-sensitive based on a fasting homeostasis model assessment (HOMA) value are eligible for the trial. At baselin...
Eligibility Criteria
Inclusion
- Diagnosis of nonischemic dilated cardiomyopathy, current NYHA class I-II congestive heart failure
- History of Stage C-D heart failure with EF ≤ 40% during the course of the disease
- Treatment with a stable comprehensive heart failure regimen for at least 3 months (including beta-blockers and ACE-inhibitors or angiotensin receptor blockers unless intolerant)
- Age \> 18 yrs
Exclusion
- Cardiomyopathy due to one of the following:
- Ischemic heart disease
- Primary valvular lesion
- Hypertrophic cardiomyopathy
- Cardiac resynchronization within the last 3 months
- Transaminase values \> 2.5 x upper limit of normal or history of liver disease
- Diagnosis of diabetes mellitus by:
- Diabetes previously diagnosed per patient history
- 2 or more fasting glucose values \> 125 mg/dl
- Current NYHA class III or IV heart failure
- Serum creatinine \> 1.6 mg/dl
- History of heart transplantation
- Pregnancy or active breast feeding
- Hospitalization for decompensated heart failure within 30 days prior to enrollment.
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
End Date :
December 1 2007
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00466713
Start Date
March 1 2007
End Date
December 1 2007
Last Update
May 13 2014
Active Locations (1)
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1
Stanford University Hospital
Stanford, California, United States, 94305