Status:
COMPLETED
Treatment of Aggression, Anger and Emotional Dysregulation in Borderline Personality Disorder
Lead Sponsor:
US Department of Veterans Affairs
Conditions:
Borderline Personality Disorder
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
This study examines the effects of 12 months of dialectical behavior therapy (DBT) for subjects with borderline personality disorder on aggression, anger and emotional dysregulation. Treatment effects...
Detailed Description
Borderline Personality Disorder (BPD) is a disabling disorder characterized by poor affect regulation and poor impulse control. This often results in impaired interpersonal relationships and maladapti...
Eligibility Criteria
Inclusion
- Able to provide written informed consent
- In good physical health as confirmed by a complete physical exam, electrocardiogram, neurological exam, and routine laboratory tests of blood and urine
- A negative urine toxicology screen
- Completion of psychiatric evaluations, medical evaluations, and self-report questionnaires through separate protocol- Biological Correlates of Personality Disorders (GCO #88-244)
- meet DSM-IV criteria for borderline personality disorder and have an overt aggression scale- modified aggression subscale score of six or above on one of two OASM pre-treatment screens.
- not currently be taking any psychiatric medications. If they have taken psychiatric medications in the past, they must be at least 2 weeks (6 half-lives) medication-free prior to participating in the study. These medications include mood stabilizers, antidepressants, antipsychotics, and benzodiazepines.
Exclusion
- meet criteria for schizophrenia, bipolar I disorder, schizoaffective disorder or any other psychotic disorder.
- have met criteria for substance abuse or dependence during the 6 months prior to entry into the study
- have a past history of intravenous drug use, cocaine abuse or dependence, or any substance dependence that resulted in serious medical sequelae
- meet criteria for current MDE, as they may require antidepressant treatment
- have made a suicide attempt or had a psychiatric hospitalization during the 6 months prior to entry into the study
- be on any psychotropic medication(s) upon entry into the study
- be in concurrent psychotherapy (case management services and work therapy programs are not considered individual psychotherapy)
- be pregnant or lactating
Key Trial Info
Start Date :
November 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00467038
Start Date
November 1 2006
End Date
September 1 2010
Last Update
August 25 2015
Active Locations (1)
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1
VA Medical Center, Bronx
The Bronx, New York, United States, 10468