Status:
TERMINATED
Mechanistically-based Optimization of UV Radiation Therapy in Psoriasis
Lead Sponsor:
VA Office of Research and Development
Collaborating Sponsors:
University Hospitals Cleveland Medical Center
Conditions:
Psoriasis
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The purpose of this study is 1) to determine whether Imiquimod or Steroid pretreatment modifies UVB laser light response resulting in increased cell death compared to UVB laser light alone; 2) to dete...
Detailed Description
The characteristic lesion of psoriasis is a sharply demarcated erythematous papule or plaque with excessive scaling due to hyperproliferating keratinocytes, infiltrating granulocytes, and a dense mono...
Eligibility Criteria
Inclusion
- The presence of plaque-type psoriasis in areas of the trunk, buttocks, or extremities that are amenable to biopsy and evaluable disease in at least 2 cm target treatment sites separated by 1 cm
- Age 18-80, both genders, all ethnicities
- No contraindications to phototherapy or biopsy procedures
- No topical steroid, tar, phototherapy, Vitamin D, or retinoid therapy to target lesions for at least 1 week prior to the study
- No systemic psoriasis therapy for at least four weeks prior to the study
- Able to give informed consent under IRB approval procedures
Exclusion
- Photosensitivity disorders
- Active untreated diseases or medication usage which may interfere with UVB, wound healing, or immune function
- Hypersensitivity to local anesthetic
- Inability to provide informed consent
- Pregnancy and /or lactating
Key Trial Info
Start Date :
May 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT00470392
Start Date
May 1 2007
End Date
July 1 2012
Last Update
October 5 2016
Active Locations (2)
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1
University Hospital Case Medical Center
Cleveland, Ohio, United States, 44106
2
VA Medical Center, Cleveland
Cleveland, Ohio, United States, 44106