Status:
COMPLETED
Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsors:
American Diabetes Association
Conditions:
Hypogonadism
Eligibility:
MALE
18-75 years
Phase:
NA
Brief Summary
Type 2 diabetes is one of the most common metabolic disorders in the U.S, estimated to affect 16 million Americans. Established risk factors for this disease include obesity, increased waist/hip ratio...
Detailed Description
The overall aim of this study is to examine the effect of testosterone on insulin sensitivity using the models of acute and chronic hypogonadism. All subjects will be in good general health and 2 grou...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Healthy men:
- Good general health,
- Normotensive,
- Normal testosterone levels,
- No medications known to influence glucose homeostasis or testosterone levels
- IHH men:
- Good general health;
- Normal thyroid, adrenal, and GH axes;
- Normal prolactin levels;
- No abnormalities on imaging of the hypothalamic-pituitary region;
- No medications known to influence glucose homeostasis;
- Must have been off hormone therapy for a suitable washout period depending on the type of prior androgen replacement
Exclusion
Key Trial Info
Start Date :
October 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2008
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00470990
Start Date
October 1 2002
End Date
June 1 2008
Last Update
April 20 2011
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02143