Status:
TERMINATED
Saliva mRNA Expression Profiling for Early Stage Non-Small Cell Lung Cancer Screening
Lead Sponsor:
Scottsdale Healthcare
Collaborating Sponsors:
University of California, Los Angeles
University of Colorado, Denver
Conditions:
Non-Small Cell Lung Cancer
Eligibility:
All Genders
40-79 years
Brief Summary
This is a pilot study to test the feasibility of using gene expression from saliva to identify patients with early-stage non-small cell lung cancer (NSCLC). The primary objective of this study is to ...
Eligibility Criteria
Inclusion
- Patients with untreated stage I-II NSCLC OR Healthy control subjects: with a \> 20 pack year history of cigarette smoking OR Never smokers (defined as less than 100 cigarettes over subject's lifetime)
- The investigators recognize that pathologic confirmation is not always available prior to surgical resection of a lung mass. To account for this, subjects with a suspicious lung mass concerning for lung cancer, can be enrolled on this trial, and submit a saliva sample prior to surgical resection (ideally within 45 days of planned surgery).
- Adults age 40-79
- Ability to understand the investigational nature of the study and sign the informed consent in accordance with institutional and FDA guidelines
Exclusion
- No active pulmonary infection, i.e. bronchitis or pneumonia for 6 months
- No use of steroid inhalers for \> 6 months
- No other prior malignancy is allowed except for adequately treated basal or squamous cell skin cancer, in situ cervical cancer, or other cancers from which the patient has been disease-free for 5 years
Key Trial Info
Start Date :
August 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2008
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00607425
Start Date
August 1 2007
End Date
July 1 2008
Last Update
July 17 2008
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