Status:
COMPLETED
Sympathetic Nerve Activity During Hypoglycemia and Exercise
Lead Sponsor:
Vanderbilt University
Conditions:
Diabetes Mellitus
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
The purpose of this study is to determine if either hypoglycemia or exercise cause differential responses in muscle and skin sympathetic nerve activity.
Detailed Description
The body has defensive responses to correct low blood sugar (hypoglycemia). A vital component of this response is release of glucagon and activation of the sympathetic nervous system, which provides t...
Eligibility Criteria
Inclusion
- 36 Healthy male and female subjects (18 males and 18 females) aged 18-40 yr
- All potential volunteers will have routine blood test to screen for hepatic, renal, and hematological abnormalities
- Body mass index ≤30kg · m-2
- Normal bedside autonomic function
- Female volunteers of childbearing potential will undergo HCG pregnancy test at screening and again on the study day.
Exclusion
- Pregnant women
- Subjects unable to give voluntary informed consent
- Subjects on anticoagulant drugs or anemic
- Subjects with a recent medical illness
- Subjects with a history of hypertension, heart disease or cerebrovascular disease
- Subjects with known liver or kidney disease
- Subjects with recent weight loss or consuming a low carbohydrate diet
Key Trial Info
Start Date :
April 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2008
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00608348
Start Date
April 1 2002
End Date
July 1 2008
Last Update
June 10 2015
Active Locations (1)
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1
Vanderbilt University
Nashville, Tennessee, United States, 37232