Status:
COMPLETED
Influence of Physostigmine on Patient-Controlled Analgesia (PCA) in Postoperative Intensive Care Patients
Lead Sponsor:
Klinikum Ludwigshafen
Collaborating Sponsors:
University of Mannheim
Conditions:
Pain
Eligibility:
All Genders
18-80 years
Brief Summary
The study is to evaluate the influence of physostigmine in the postoperative period in intensive care patients considering pain quality, opioid consumption, hemodynamics and mobilisation.
Detailed Description
Pain management is of major concern in the postoperative period, mostly based on opioids. In numerous experimental and clinical trials cholinergic mechanisms have been demonstrated to play an importan...
Eligibility Criteria
Inclusion
- Age 18-80 years
- Indication for postoperative pain therapy and admission to ICU
- ASA I-III
- Weight 50-125 kg
- Patients that are willing to participate in the present study
Exclusion
- Peridural anesthesia for pain management
- Severe left ventricular function (EF \<30%)
- Severe/exacerbated COPD; Asthma
- ASA IV-V
- Chronic renal insufficiency(Creatinine \> 1,5 mg/dl)
- Ulcera ventriculi
- Known allergy to any of the study agents
- Hb preoperative \<9,5 g/dl
- Alcohol,drug and/or tablet abuse (Opioids, NSAR)
- Emergency operation
- Pregnancy
- Women of childbearing age and without a negative pregnancy test
- Severe liver disease (GOT oder GPT \> 45 U/L)
- Severe neurologica derangements (e.g. M. Parkinson, Multiple Sklerosis)
- History of apoplexia \<6 Monate or residua
- Perioperative myocardial infarction
- Patients that are not able to agree to the present study
- Patients that refuse to participate in the present study
- Patients that are part of any other study
Key Trial Info
Start Date :
January 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2007
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00608621
Start Date
January 1 2007
End Date
October 1 2007
Last Update
February 6 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Klinkum Ludwigshafen, Department of Anesthesiology
Ludwigshafen, Germany, D-67063