Status:
ACTIVE_NOT_RECRUITING
Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)
Lead Sponsor:
Brigham and Women's Hospital
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Pulmonary Disease, Chronic Obstructive
Emphysema
Eligibility:
All Genders
45-80 years
Brief Summary
Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is often caused by cigarette smoking. The purpose of this study is to evaluate whether certain genetic factors predispose ...
Detailed Description
COPD is a disease in which the lung airways are damaged and partly obstructed, making it difficult to breathe. Millions of people in the United States have COPD, and it is the third leading cause of d...
Eligibility Criteria
Inclusion
- At least 10 pack-years of cigarette smoking (although a of nonsmoking controls is also being enrolled)
- Self-designation of non-Hispanic white or African-American
Exclusion
- Other lung diseases (except for asthma in participants with COPD)
- Pregnant
- Cancer (other than skin cancer) in the 5 years prior to study entry
- Received antibiotics for a COPD exacerbation in the 1 month prior to study entry
- First- or second-degree relative of a previously enrolled study participant
Key Trial Info
Start Date :
November 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2028
Estimated Enrollment :
10718 Patients enrolled
Trial Details
Trial ID
NCT00608764
Start Date
November 1 2007
End Date
August 1 2028
Last Update
September 17 2025
Active Locations (20)
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1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35249
2
University of California at San Diego
San Diego, California, United States, 92103
3
Los Angeles Biomedical Research Institute
Torrance, California, United States, 90502
4
National Jewish Health
Denver, Colorado, United States, 80206